CD15 expression in human myeloid cell differentiation is regulated by sialidase activity

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CD15 expression in human myeloid cell differentiation is regulated by sialidase activity.

The glycan determinant CD15 (also known as Lewis x, or Le(x)) is a distinguishing marker for human myeloid cells and mediates neutrophil adhesion to dendritic cells. Despite broad interest in this structure, the mechanisms underlying CD15 expression remain relatively uncharacterized. Accordingly, we investigated the molecular basis of increasing CD15 expression associated with human myeloid cel...

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ژورنال

عنوان ژورنال: Nature Chemical Biology

سال: 2008

ISSN: 1552-4450,1552-4469

DOI: 10.1038/nchembio.116